Pain Symptoms in Optic Neuritis

Xiayin Yang; Xuefen Li; Mengying Lai; Jincui Wang; Shaoying Tan; Henry Ho-Lung Chan

doi:10.3389/fpain.2022.865032

Pain Symptoms in Optic Neuritis

Front Pain Res (Lausanne). 2022 Apr 14:3:865032. doi: 10.3389/fpain.2022.865032. eCollection 2022.

Authors

Xiayin Yang^{1

2}, Xuefen Li^{3

4}, Mengying Lai^{4

5}, Jincui Wang⁴, Shaoying Tan^{1

6

7}, Henry Ho-Lung Chan^{1

6

7

8}

Affiliations

¹ School of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
² Department of Ophthalmology, The First Affiliated Hospital of the Medical College of Shantou University, Shantou, China.
³ Department of Vascular Neurosurgery, The First Affiliated Hospital of the Medical College of Shantou University, Shantou, China.
⁴ Shantou University Medical College, Guangdong, China.
⁵ Department of Ophthalmology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
⁶ Research Centre for SHARP Vision (RCSV), The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China.
⁷ Center for Eye and Vision Research (CEVR), Hong Kong, Hong Kong SAR, China.
⁸ University Research Facilities in Behavioral and Systems Neuroscience (UBSN), The Hong Kong Polytechnic University, Hong Kong, Hong Kong SAR, China.

Abstract

Signs and symptoms of optic neuritis (ON), an autoimmune disorder of the central nervous system (CNS), differ between patients. Pain, which is commonly reported by ON patients, may be the major reason for some patients to visit the clinic. This article reviews the presence of pain related to ON with respect to underlying disorders, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein associated disease (MOGAD). The aim of this review is to provide an overview of pain symptoms in accordance with the context of various pathophysiological explanations, assist in differential diagnosis of ON patients, especially at the onset of disease, and make recommendations to aid physicians make decisions for follow up diagnostic examinations.

Keywords: mechanism; multiple sclerosis; myelin oligodendrocyte glycoprotein associated disease; neuromyelitis optica spectrum disorder; optic neuritis; pain; treatment.

Publication types

Review