First-in-Human Computational Preprocedural Planning of Left Main Interventions Using a New Everolimus-Eluting Stent

Yiannis S Chatzizisis; Janaki Makadia; Shijia Zhao; Anastasios Panagopoulos; Mohammadali Sharzehee; Behram Khan; Saurabhi Samant; Muhammad Fayaz; Jitendra Pandya; Haysam Akkad; Gregory Pavlides; Edward O'Leary; Wei Wu

doi:10.1016/j.jaccas.2022.02.001

First-in-Human Computational Preprocedural Planning of Left Main Interventions Using a New Everolimus-Eluting Stent

JACC Case Rep. 2022 Mar 16;4(6):325-335. doi: 10.1016/j.jaccas.2022.02.001.

Affiliations

¹ Cardiovascular Biology and Biomechanics Laboratory, Cardiovascular Division, University of Nebraska Medical Center, Omaha, Nebraska, USA.
² Cardiovascular Division, University of Nebraska Medical Center, Omaha, Nebraska, USA.

Abstract

Left main coronary artery stenting requires rigorous planning and optimal execution. This case series presents a new approach to left main stenting guided by preprocedural patient-specific computational simulations. Three patients with significant left main artery disease underwent simulation-guided intervention using a novel stent scaffold purpose-built for large coronary arteries. (Level of Difficulty: Advanced.).

Keywords: 3D, 3-dimensional; CAD, coronary artery disease; CFD, computational fluid dynamics; HD IVUS, high-definition intravascular ultrasound; LAD, left anterior descending; LCx, left circumflex; LM, left main; PCI, percutaneous coronary intervention; computational simulations; coronary artery disease; imaging; left main; percutaneous coronary interventions; stents.

Publication types

Case Reports

Grants and funding

R01 HL144690/HL/NHLBI NIH HHS/United States