Bioactive silver phosphate/polyindole nanocomposites

Soumik Podder; Samrat Paul; Piyali Basak; Bowen Xie; Nigel J Fullwood; Sara J Baldock; Ying Yang; John G Hardy; Chandan K Ghosh

doi:10.1039/d0ra01129k

Bioactive silver phosphate/polyindole nanocomposites

RSC Adv. 2020 Mar 17;10(19):11060-11073. doi: 10.1039/d0ra01129k. eCollection 2020 Mar 16.

Authors

Soumik Podder^{1

2}, Samrat Paul³, Piyali Basak³, Bowen Xie⁴, Nigel J Fullwood⁵, Sara J Baldock⁶, Ying Yang⁴, John G Hardy^{6

7}, Chandan K Ghosh¹

Affiliations

¹ School of Materials Science and Nanotechnology, Jadavpur University Kolkata-700032 India chandu_ju@yahoo.co.in.
² Department of Electronics and Telecommunication Engineering, C V Raman Global University Mahura Khorda Orissa-752054 India.
³ School of Bioscience and Biomedical Engineering, Jadavpur University Kolkata-700032 India.
⁴ Institute for Science and Technology in Medicine, School of Medicine, Keele University Stoke-on-Trent ST4 6QG UK.
⁵ Department of Biomedical and Life Sciences, Lancaster University Lancaster LA1 4YG UK.
⁶ Department of Chemistry, Lancaster University Lancaster Lancashire LA1 4YB UK j.g.hardy@lancaster.ac.uk.
⁷ Materials Science Institute, Lancaster University Lancaster Lancashire LA1 4YB UK.

Abstract

Materials capable of releasing reactive oxygen species (ROS) can display antibacterial and anticancer activity, and may also have anti-oxidant capacity if they suppress intracellular ROS (e.g. nitric oxide, NO) resulting in anti-inflammatory activity. Herein we report silver phosphate (Ag₃PO₄)/polyindole (Pln) nanocomposites which display antibacterial, anticancer and anti-inflammatory activity, and have therefore potential for a variety of biomedical applications.