Co-crystallization of antibacterials with inorganic salts: paving the way to activity enhancement

Oleksii Shemchuk; Dario Braga; Fabrizia Grepioni; Raymond J Turner

doi:10.1039/c9ra10353h

Co-crystallization of antibacterials with inorganic salts: paving the way to activity enhancement

RSC Adv. 2020 Jan 10;10(4):2146-2149. doi: 10.1039/c9ra10353h. eCollection 2020 Jan 8.

Authors

Oleksii Shemchuk¹, Dario Braga¹, Fabrizia Grepioni¹, Raymond J Turner²

Affiliations

¹ Molecular Crystal Engineering Laboratory, Dipartimento di Chimica "G. Ciamician", Università di Bologna Via F. Selmi 2 40126 Bologna Italy dario.braga@unibo.it.
² Department of Biological Sciences, University of Calgary 2500 University Drive NW Calgary Alberta T2N 1N4 Canada turnerr@ucalgary.ca.

Abstract

Co-crystallization of the antibacterial agents proflavine and methyl viologen with the inorganic salts CuCl, CuCl₂ and AgNO₃ results in enhanced antimicrobial activity with respect to the separate components.