Aerobic copper-promoted oxidative dehydrosulfurative carbon-oxygen cross-coupling of 3,4-dihydropyrimidine-1 H-2-thiones with alcohols

Jihong Lee; Yujeong Kwon; Dong-Chan Lee; Jeong-Hun Sohn

doi:10.1039/d1ra07713a

Aerobic copper-promoted oxidative dehydrosulfurative carbon-oxygen cross-coupling of 3,4-dihydropyrimidine-1 H-2-thiones with alcohols

RSC Adv. 2021 Nov 17;11(58):36821-36825. doi: 10.1039/d1ra07713a. eCollection 2021 Nov 10.

Authors

Jihong Lee¹, Yujeong Kwon¹, Dong-Chan Lee², Jeong-Hun Sohn¹

Affiliations

¹ Department of Chemistry, Chungnam National University Daejeon 34134 Republic of Korea sohnjh@cnu.ac.kr.
² Department of Chemistry and Biochemistry, University of Nevada Las Vegas 4505 S. Maryland Parkway, Box 454003 Las Vegas Nevada 89154-4003 USA Dong-Chan.Lee@unlv.edu.

Abstract

An aerobic Cu-promoted oxidative dehydrosulfurative carbon-oxygen cross-coupling of 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) with both aliphatic and aromatic alcohols is described. Together with the ready availability of DHPMs and both alcohols, the method furnishes facile access to biologically valuable 2-alkoxypyrimidines with rapid diversification.