Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage

Jiangkun Huang; Lan Luo; Naiguo Xing; Linghui Gu; Chen Li; Qiao Han; Shilong Zheng; Ling He

doi:10.1039/d0ra01408g

Novel synthesis of divergent aryl imidazoles from ketones involving copper-catalyzed α-amination and oxidative C-C bond cleavage

RSC Adv. 2020 Apr 6;10(23):13815-13819. doi: 10.1039/d0ra01408g. eCollection 2020 Apr 1.

Authors

Jiangkun Huang¹, Lan Luo¹, Naiguo Xing¹, Linghui Gu¹, Chen Li¹, Qiao Han¹, Shilong Zheng², Ling He¹

Affiliations

¹ Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University Chengdu Sichuan 610041 P. R. China heling2012@scu.edu.cn.
² Department of Chemistry and RCMI Cancer Research Center, Xavier University of Louisiana New Orleans LA 70125 USA.

Abstract

A one-pot synthesis, initiated by a copper salt with inorganic (NH₄)₂CO₃ as the nitrogen source, forms divergent aryl imidazole derivatives from ketones via α-amination and oxidative C-C bond cleavage reactions. The approach provides a simple and rapid synthesis of imidazole derivatives and has certain versatility.