Comparisons of Serum Interleukin-8 Levels in Major Depressive Patients With Drug-Free Versus SSRIs Versus Healthy Controls

Zhen Hua Zhu; Xiao Ying Song; Li Juan Man; Peng Chen; Zhen Tang; Rong Hua Li; Cai Fang Ji; Ning Bin Dai; Fang Liu; Jing Wang; Jianping Zhang; Qiu Fang Jia; Li Hui

doi:10.3389/fpsyt.2022.858675

Comparisons of Serum Interleukin-8 Levels in Major Depressive Patients With Drug-Free Versus SSRIs Versus Healthy Controls

Front Psychiatry. 2022 Apr 14:13:858675. doi: 10.3389/fpsyt.2022.858675. eCollection 2022.

Authors

Affiliations

¹ Research Center of Biological Psychiatry, Suzhou Guangji Hospital, Medical College of Soochow University, Suzhou, China.
² Suzhou Center for Disease Prevention and Control, Suzhou, China.
³ Department of Psychiatry, Weill Cornell Medical College, Cornell University, New York, NY, United States.

Abstract

Objective: The interleukin-8 (IL-8) has been reported to play an important role in depression, which might be modulated by the selective serotonin reuptake inhibitors (SSRIs). Thus, the aim of this study was to investigate serum IL-8 levels, depressive symptom, and their associations in drug-free MDD patients, MDD patients with SSRIs, and healthy controls (HCs).

Methods: Fifty-seven drug-free MDD patients (male/female = 35/22, mean age: 39.24 years), 30 MDD patients with SSRIs (male/female = 11/19, mean age: 39.73 years), and 101 HCs (male/female = 52/49, mean age: 37.38 years) were recruited in this cross-sectional study. Serum IL-8 levels and depressive symptom were assessed using the Flow Cytometer and Hamilton Depression Scale (HAMD). The analysis of variance was used for the comparison between groups. The relationship between serum log₁₀ IL-8 levels and HAMD score was analyzed by Pearson correlation.

Results: Serum log₁₀IL-8 levels were lower in all patients than HCs after controlling for covariates (F = 4.86, p = 0.03). There was significant difference in serum Log₁₀IL-8 levels among three groups after controlling for covariates (F = 14.63, p < 0.001). Serum Log₁₀IL-8 levels in drug-free patients were lower compared to HCs (F = 19.38, p < 0.001) or patients with SSRIs (F = 21.89, p < 0.001) after controlling for covariates. However, there was not difference in serum log₁₀IL-8 levels between patients with SSRIs and HCs after controlling for covariates. Moreover, serum Log₁₀IL-8 levels were negatively correlated with HAMD score in all patients (r = -0.37, p = 0.02). Also, serum Log₁₀IL-8 levels were negatively correlated with HAMD score in drug-free patients (r = -0.74, p = 0.01), but not in patients with SSRIs.

Conclusion: Our data supported that the decline in serum IL-8 levels was association with depression. Moreover, the SSRIs might modulate increased serum IL-8 levels of depression.

Keywords: SSRIs; association; depressive symptom; interleukin-8; major depressive disorder.