An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment

Dan Luo; Cuijuan Wang; Yan Tong; Cheng Liu; Yumei Xiao; Zixin Zhu; DongNing Liu; Yaoyu Wang

doi:10.1039/d0ra00108b

An NIF-doped ZIF-8 hybrid membrane for continuous antimicrobial treatment

RSC Adv. 2020 Feb 19;10(13):7360-7367. doi: 10.1039/d0ra00108b. eCollection 2020 Feb 18.

Authors

Dan Luo¹, Cuijuan Wang¹, Yan Tong¹, Cheng Liu¹, Yumei Xiao¹, Zixin Zhu¹, DongNing Liu¹, Yaoyu Wang²

Affiliations

¹ School of Life Science and Engineering, Southwest Jiaotong University Chengdu 610000 China wangcuijuan@home.swjtu.edu.cn.
² Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry, Northwest University Xi'an 710069 China.

Abstract

Sodium alginate (ALG) composites with ZIF-8 and niflumic acid (NIF) were prepared by a one-pot method at room temperature and characterized by FTIR, SEM and XRD studies. In the composite, ZIF-8 was used as a highly connected node in a supercrosslinked polymer network. In addition, the material exhibits good antibacterial activity against Staphylococcus aureus and Escherichia coli in vitro. Compared to the original ALG membrane and ZIF-8, the ZIF-NIF-ALG membrane has the following advantages: stronger antibacterial properties; slow release of Zn(ii); high drug loading; and longer sustained release time. This research introduces new concepts for the design and manufacture of various antimicrobial membranes and broadens the range of applications of MOFs.