Pythiosis in a patient with Acute Myeloid Leukemia: Diagnosis and clinical course

Parijat Das; Arpita Bhattacharyya; Parthasarathi Bhattacharyya; Kingshuk Dhar; Krishnendu Das; Sanjay Bhattacharya

doi:10.1016/j.mycmed.2022.101279

Pythiosis in a patient with Acute Myeloid Leukemia: Diagnosis and clinical course

J Mycol Med. 2022 Aug;32(3):101279. doi: 10.1016/j.mycmed.2022.101279. Epub 2022 Apr 22.

Authors

Parijat Das¹, Arpita Bhattacharyya², Parthasarathi Bhattacharyya², Kingshuk Dhar³, Krishnendu Das³, Sanjay Bhattacharya³

Affiliations

¹ Department of Microbiology, Tata Medical Center, Kolkata, India. Electronic address: parijat.das@tmckolkata.com.
² Department of Pediatric Oncology, Tata Medical Center, Kolkata, India.
³ Department of Microbiology, Tata Medical Center, Kolkata, India.

PMID: 35490571
DOI: 10.1016/j.mycmed.2022.101279

Abstract

Pythiosis, caused by Pythium insidiosum (a fungal-like stramenipila, a group of eukaryotes away from the true fungi). Pythium insidiosum causes rare human and animal infections. Transmission from animals to human is yet to be reported. Wet soil and plants near watery environments are the source of infection. We report here a fatal case of human pythiosis in a 9-year old child with acute myeloid leukemia. Organism was identified by DNA sequencing.

Keywords: Leukemia; Mycology; Pythiosis; Pythium insidiosum; Sanger sequencing.

Publication types

Case Reports

MeSH terms

Animals
Child
Humans
Leukemia, Myeloid, Acute* / complications
Leukemia, Myeloid, Acute* / diagnosis
Pythiosis* / diagnosis
Pythium*
Sequence Analysis, DNA