Preparation of novel self-assembled albumin nanoparticles from Camellia seed cake waste for lutein delivery

Ningxiang Yu; Shengxin Shao; Weiwei Huan; Qin Ye; Xiaohua Nie; Yuanchao Lu; Xianghe Meng

doi:10.1016/j.foodchem.2022.133032

Preparation of novel self-assembled albumin nanoparticles from Camellia seed cake waste for lutein delivery

Food Chem. 2022 Sep 30:389:133032. doi: 10.1016/j.foodchem.2022.133032. Epub 2022 Apr 21.

Authors

Ningxiang Yu¹, Shengxin Shao¹, Weiwei Huan², Qin Ye³, Xiaohua Nie¹, Yuanchao Lu¹, Xianghe Meng⁴

Affiliations

¹ College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
² College of Chemistry and Materials Engineering, Zhejiang A & F University, Hangzhou 311300, Zhejiang, China.
³ Institute of Food Sciences, Zhejiang Academy of Agricultural Sciences, Hangzhou 310014, Zhejiang, China.
⁴ College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China. Electronic address: mengxh@zjut.edu.cn.

PMID: 35490515
DOI: 10.1016/j.foodchem.2022.133032

Abstract

The potential utilization value of Camellia seed cake was explored by extracting albumin (CSCA) to develop nanoparticles for lutein delivery. First, thermal property and amphiphilicity of CSCA were evaluated to guide nanoparticle preparation. Next, CSCA nanoparticles modified with chitosan (CS) were prepared through a thermally induced self-assembly method derived by electrostatic attraction and hydrophobic interaction. The optimized nanoparticles were prepared from CSCA:CS at a mass ratio of 2:1 with pH of 4.5, and an incubation temperature and time of 80 ℃ and 10 min, respectively. The nanoparticles had the highest effective loading capacity for lutein at 5.89 ± 0.78%, and the corresponding encapsulation efficiency was 43.82 ± 5.69%. The storage stability of lutein was improved by nanoparticle loading, and the bioaccessibility of lutein in simulated intestinal digestion increased from 26.8 ± 4.4% to 57.3 ± 9.6% after encapsulation into nanoparticles. These findings may facilitate the development of new and sustainable proteins from plant waste for delivery system applications.

Keywords: Albumin; Camellia seed cake; Delivery system; Lutein; Nanoparticles.

MeSH terms

Albumins
Camellia*
Chitosan* / chemistry
Drug Carriers / chemistry
Lutein / chemistry
Nanoparticles* / chemistry
Particle Size
Seeds

Substances

Albumins
Drug Carriers
Chitosan
Lutein