Osteoclastogenesis inhibitory phenolic derivatives produced by the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501

Humu Lu; Yanhui Tan; Yanting Zhang; Zhichao Li; Jinying Chen; Chenghai Gao; Yonghong Liu; Xiaowei Luo

doi:10.1016/j.fitote.2022.105201

Osteoclastogenesis inhibitory phenolic derivatives produced by the Beibu Gulf coral-associated fungus Acremonium sclerotigenum GXIMD 02501

Fitoterapia. 2022 Jun:159:105201. doi: 10.1016/j.fitote.2022.105201. Epub 2022 Apr 27.

Authors

Humu Lu¹, Yanhui Tan², Yanting Zhang¹, Zhichao Li², Jinying Chen¹, Chenghai Gao¹, Yonghong Liu³, Xiaowei Luo⁴

Affiliations

¹ Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China.
² State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.
³ Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China. Electronic address: yonghongliu@scsio.ac.cn.
⁴ Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China. Electronic address: luoxiaowei1991@126.com.

PMID: 35489580
DOI: 10.1016/j.fitote.2022.105201

Abstract

Three new chlorinated orsellinic aldehyde derivatives, orsaldechlorins A - C (1-3) and a naturally new brominated orsellinic acid (7), along with ten known biosynthetically related phenolic (4-6, 8-13) and cyclohexanone (14) derivatives, were identified from the Beibu Gulf coral-derived fungus Acremonium sclerotigenum GXIMD 02501. Their structures were determined by spectroscopic data interpretation and comparison with those reported in the literature. Several of them showed inhibition of lipopolysaccharide (LPS)-induced NF-κB activation in RAW 264.7 macrophages at 20 μM. Moreover, the two new potent inhibitors (1 and 2) suppressed RANKL-induced osteoclast differentiation without cytotoxicity in bone marrow macrophages cells (BMMs). Our findings reveal that the phenolic compounds could be potential candidates for the prevention and treatment of osteolytic bone diseases.

Keywords: Acremonium sclerotigenum; Beibu Gulf; Marine fungi; Osteoclastogenesis; Phenolic derivatives.

MeSH terms

Acremonium
Agaricales*
Animals
Anthozoa*
Bone Resorption*
Cell Differentiation
Molecular Structure
NF-kappa B / metabolism
Osteoclasts
Osteogenesis
RANK Ligand

Substances

NF-kappa B
RANK Ligand

Supplementary concepts

Acremonium sclerotigenum