Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache

Mol Cell Biochem. 2022 Sep;477(9):2269-2296. doi: 10.1007/s11010-022-04438-9. Epub 2022 Apr 28.

Abstract

Migraine is a common, debilitating disorder for which attacks typically result in a throbbing, pulsating headache. Although much is known about migraine, its complexity renders understanding the complete etiology currently out of reach. However, two important facts are clear, the brain and the metabolism of the migraineur differ from that of the non-migraineur. This review centers on the altered amino acid metabolism in migraineurs and how it helps define the pathology of migraine.

Keywords: Chronic migraine; Episodic migraine; Trace amine; Tryptophan metabolites.

Publication types

  • Review

MeSH terms

  • Amino Acids*
  • Headache
  • Humans
  • Migraine Disorders*
  • Signal Transduction

Substances

  • Amino Acids