Small Heat Shock Proteins in Retinal Diseases

Vivian Rajeswaren; Jeffrey O Wong; Dana Yabroudi; Rooban B Nahomi; Johanna Rankenberg; Mi-Hyun Nam; Ram H Nagaraj

doi:10.3389/fmolb.2022.860375

Small Heat Shock Proteins in Retinal Diseases

Front Mol Biosci. 2022 Apr 11:9:860375. doi: 10.3389/fmolb.2022.860375. eCollection 2022.

Authors

Vivian Rajeswaren¹, Jeffrey O Wong¹, Dana Yabroudi¹, Rooban B Nahomi¹, Johanna Rankenberg¹, Mi-Hyun Nam¹, Ram H Nagaraj^{1

2}

Affiliations

¹ Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, School of Medicine, Aurora, CO, United States.
² Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, United States.

Abstract

This review summarizes the latest findings on small heat shock proteins (sHsps) in three major retinal diseases: glaucoma, diabetic retinopathy, and age-related macular degeneration. A general description of the structure and major cellular functions of sHsps is provided in the introductory remarks. Their role in specific retinal diseases, highlighting their regulation, role in pathogenesis, and possible use as therapeutics, is discussed.

Keywords: age-related macular degeneration; diabetic retinopathy; glaucoma; retina; small heat shock proteins.

Publication types

Review