Characteristics of the Fractional Amplitude of Low-Frequency Fluctuation in Ocular Hypertension Patients: A Resting-State fMRI Study

Ying Liang; Yi-Cong Pan; Hui-Ye Shu; Xue-Mei Chou; Qian-Min Ge; Li-Juan Zhang; Qiu-Yu Li; Rong-Bing Liang; Han-Lin Li; Yi Shao

doi:10.3389/fmed.2021.687420

Characteristics of the Fractional Amplitude of Low-Frequency Fluctuation in Ocular Hypertension Patients: A Resting-State fMRI Study

Front Med (Lausanne). 2022 Apr 8:8:687420. doi: 10.3389/fmed.2021.687420. eCollection 2021.

Authors

Affiliation

¹ Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ophthalmology Institute and Ocular Disease Clinical Research Centre, Nanchang, China.

Abstract

Background: The fractional amplitude of low-frequency fluctuation (fALFF) method has been underutilized in research on the pathogenesis and clinical manifestations of ocular hypertension (OH).

Purpose: This study uses resting state functional magnetic resonance imaging (rs-fMRI) and fALFF to investigate the nature of spontaneous brain activity in OH patients and the relationship, if any, between changes in activity and clinical features.

Materials and methods: A total of 18 subjects (9 females and 9 males) with ocular hypertension (OH) and 18 healthy controls (HCs) matched for gender, age, and educational level were recruited to this study. All participants underwent an rs-fMRI scan, and spontaneous brain activity was assessed using the fALFF method. Receiver operating characteristic curves were plotted to investigate differences between OH and HC groups.

Results: The fALFF values of OH patients were significantly higher in the left precuneus lobe (LP), compared with the same region in controls (P < 0.05). Conversely, values in the left anterior cingulate lobe (LAC), were significantly lower (P < 0.05) in OH than in controls. However, no significant association was found between the mean fALFF values and clinical characteristics in either brain area.

Conclusion: High spontaneous activity in two brain areas may reflect neuropathological mechanisms underpinning visual impairment in OH patients.

Keywords: fractional amplitude of low-frequency fluctuation; left anterior cingulate cortex; left precuneus; ocular hypertension; resting state functional magnetic resonance imaging.