Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53

Meng Zhang; Delong Chen; Ning Zeng; Zhendong Liu; Xiao Chen; Hefang Xiao; Likang Xiao; Zeming Liu; Yonghui Dong; Jia Zheng

doi:10.3389/fcell.2022.820922

Hesperidin Ameliorates Dexamethasone-Induced Osteoporosis by Inhibiting p53

Front Cell Dev Biol. 2022 Apr 11:10:820922. doi: 10.3389/fcell.2022.820922. eCollection 2022.

Authors

Meng Zhang^{1

2}, Delong Chen³, Ning Zeng⁴, Zhendong Liu^{2

5}, Xiao Chen^{1

2}, Hefang Xiao^{1

2}, Likang Xiao^{1

2}, Zeming Liu⁴, Yonghui Dong^{1

2}, Jia Zheng¹

Affiliations

¹ Department of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou, China.
² Microbiome Laboratory, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou, China.
³ Department of Orthopaedics, Erasmus University Medical Center, Rotterdam, Netherlands.
⁴ Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
⁵ Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Henan University People's Hospital, Zhengzhou, China.

Abstract

Osteoporosis is one of the most frequent skeletal disorders and a major cause of morbidity and mortality in the expanding aging population. Evidence suggests that hesperidin may have a therapeutic impact on osteoporosis. Nevertheless, little is known about the role of hesperidin in the development of osteoporosis. Bioinformatics analyses were carried out to explore the functions and possible molecular mechanisms by which hesperidin regulates osteogenic differentiation. In the present study, we screened and harvested 12 KEGG pathways that were shared by hesperidin-targeted genes and osteoporosis. The p53 signaling pathway was considered to be a key mechanism. Our in vitro results showed that hesperidin partially reversed dexamethasone-induced inhibition of osteogenic differentiation by suppressing the activation of p53, and suggest that hesperidin may be a promising candidate for the treatment against dexamethasone-induced osteoporosis.

Keywords: KEGG; bioinformatics; hesperidin; osteoporosis; p53.