NAFLD-related hepatocellular carcinoma: The growing challenge

Pir Ahmad Shah; Rashmee Patil; Stephen A Harrison

doi:10.1002/hep.32542

NAFLD-related hepatocellular carcinoma: The growing challenge

Hepatology. 2023 Jan 1;77(1):323-338. doi: 10.1002/hep.32542. Epub 2022 Nov 8.

Authors

Pir Ahmad Shah¹, Rashmee Patil², Stephen A Harrison³

Affiliations

¹ Department of Internal Medicine , University of Texas Health Science Center , San Antonio , Texas , USA.
² South Texas Research Institute , Edinburg , Texas , USA.
³ Radcliffe Department of Medicine , University of Oxford , Oxford , UK.

Abstract

Hepatocellular carcinoma (HCC) is a common cause of cancer-related mortality and morbidity worldwide. With the obesity pandemic, NAFLD-related HCC is contributing to the burden of disease exponentially. Genetic predisposition and clinical risk factors for NAFLD-related HCC have been identified. Cirrhosis is a well-known and major risk factor for NAFLD-related HCC. However, the occurrence of NAFLD-related HCC in patients without cirrhosis is increasingly recognized and poses a significant challenge regarding cancer surveillance. It is of paramount importance to develop optimal risk stratification scores and models to identify subsets of the population at high risk so they can be enrolled in surveillance programs. In this review, we will discuss the risks and prediction models for NAFLD-related HCC.

Publication types

Review

MeSH terms

Carcinoma, Hepatocellular* / epidemiology
Carcinoma, Hepatocellular* / etiology
Humans
Liver Cirrhosis / complications
Liver Cirrhosis / epidemiology
Liver Neoplasms* / epidemiology
Liver Neoplasms* / etiology
Non-alcoholic Fatty Liver Disease* / complications
Non-alcoholic Fatty Liver Disease* / epidemiology
Risk Factors