Introduction: Impacts of COVID-19 mitigation measures on seasonal respiratory viruses is unknown in sub-tropical climates.
Methods: We compared weekly testing and test-positivity of respiratory infections in the 2019-2020 respiratory season to the 2012-2018 seasons in southern Puerto Rico using Wilcoxon signed rank tests.
Results: Compared to the average for the 2012-2018 seasons, test-positivity was significantly lower for Influenza A (p<0.001) & B (p<0.001), respiratory syncytial virus (RSV) (p<0.01), respiratory adenovirus (AdV) (p<0.05), and other respiratory viruses (p<0.001) following March 2020 COVID-19 stay at home orders.
Conclusions: Mitigation measures and behavioral social distancing choices may have reduced respiratory viral spread in southern Puerto Rico.