Nonlinear effects of environment on childhood asthma susceptibility

Pediatr Allergy Immunol. 2022 Apr;33(4):e13777. doi: 10.1111/pai.13777.

Dilini M Kothalawala^{1

2}, Veronique B N Weiss¹, Latha Kadalayil^{1

3}, Raquel Granell⁴, John A Curtin^{5

6}, Clare S Murray⁵, Angela Simpson⁵, Adnan Custovic⁷, William J Tapper¹, Faisal I Rezwan^{1

8}, Syed Hasan Arshad^{1

3

9}, John W Holloway^{1

2}; STELAR/UNICORN investigators

STELAR/UNICORN investigators:
Graham C Roberts, Steve W Turner, Sadia Haider, Sara Fontanella, Paul Cullinan

¹ Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.
² NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK.
³ Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
⁴ MRC Integrative Epidemiology Unit, Bristol Medical School, University of Bristol, Bristol, UK.
⁵ Division of Infection, Immunity, and Respiratory Medicine, Manchester Academic Health Science Centre, School of Biological Sciences, Manchester University Hospital NHS Foundation Trust, University of Manchester, Manchester, UK.
⁶ NIHR Manchester Biomedical Research Unit, Manchester, UK.
⁷ Imperial College of Science, Technology, and Medicine, National Heart and Lung Institute, London, UK.
⁸ Department of Computer Science, Aberystwyth University, Aberystwyth, UK.
⁹ The David Hide Asthma and Allergy Research Centre, St. Mary's Hospital, Newport, Isle of Wight, UK.

No abstract available

Keywords: ALSPAC; PRS-by-environment interactions; childhood asthma; meta-analysis; parental smoking; polygenic risk score.

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