Associations between Intra-Individual Neurocognitive Variability and Prospective Memory in Veterans with Mild Traumatic Brain Injury History and Posttraumatic Stress Disorder

Arch Clin Neuropsychol. 2022 Aug 23;37(6):1221-1227. doi: 10.1093/arclin/acac014.

Abstract

Objective: Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) frequently co-occur and are associated with neurocognitive intra-individual variability (IIV) and difficulty with prospective memory (PM). The current study aimed to examine associations between IIV and PM in this comorbid group.

Method: Fifty veterans with a history of blast mTBI and current comorbid PTSD completed a standardized neurocognitive battery to measure IIV, and the Memory for Intentions Screening Test measuring PM.

Results: Adjusting for age, education, and race, higher IIV was associated with poorer time-based PM (p < .001, f2 = .34), but not event-based PM. In a subset of the sample with self-report data, higher IIV was associated with poorer self-reported retrospective memory, but not PM.

Conclusions: Cognitive variability on a standardized neuropsychological battery was associated with strategically demanding PM, which is an ecologically relevant ability and highlights the possible connection between subtle cognitive difficulties in-clinic and those experienced in daily life.

Keywords: Assessment; Executive functions; Head injury; Learning and memory; Posttraumatic stress disorder; Traumatic brain injury.

MeSH terms

  • Afghan Campaign 2001-
  • Brain Concussion* / complications
  • Brain Concussion* / psychology
  • Humans
  • Iraq War, 2003-2011
  • Memory Disorders / complications
  • Memory, Episodic*
  • Neuropsychological Tests
  • Retrospective Studies
  • Stress Disorders, Post-Traumatic* / complications
  • Stress Disorders, Post-Traumatic* / psychology
  • Veterans* / psychology