Pathological and Evolutive Correlations in Steroid Resistant Nephrotic Syndrome in Children

Iuliana Magdalena Starcea; Roxana Alexandra Bogos; Georgiana Scurtu; Mihaela Munteanu; Radu Russu; Vasile Valeriu Lupu; Ancuta Lupu; Laura Trandafir; Ingrith Crenguta Miron; Maria Adriana Mocanu

doi:10.2147/IJGM.S348346

Pathological and Evolutive Correlations in Steroid Resistant Nephrotic Syndrome in Children

Int J Gen Med. 2022 Apr 19:15:4187-4193. doi: 10.2147/IJGM.S348346. eCollection 2022.

Affiliations

¹ Pediatrics Department, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
² Nephrology Division, St. Mary's Emergency Children Hospital, Iasi, Romania.

Abstract

Background: Nephrotic syndrome (NS) is the term used for the association of edema and massive proteinuria. From a therapeutic point of view, it is important to distinguish between primitive and secondary kidney damage. The clinical evolution, prognosis and therapeutic response in the NS in children are directly determined by the anatomopathological aspect. Steroid resistant nephrotic syndrome was diagnosed in patients with idiopathic NS based on lack of complete remission despite treatment with steroids.

Purpose: To analyse the anatomopathological aspects of steroid resistant nephrotic syndrome (SRNS) and their correlation with evolution.

Materials and methods: We made a retrospective study with the aim to analyze the anatomo-pathological aspects and their correlations with evolution in 68 cases of steroid resistant nephrotic syndrome (SRNS) hospitalized in the Pediatric Nephrology Department in Iaşi, Romania. We defined SRNS in all cases without response to corticosteroids after the first month of therapy. For all the cases selected, the period of follow-up was the minimal 6 months.

Results and discussions: A 36% case of nephrotic syndrome was corticoresistant, with the mean age at onset of patients with SRNS being 9.18 years, compared to KDIGO studies in which the corticosteroid resistance is 10-20%. Renal biopsy was performed in 80.88% children with SRNS and was allowed the evaluation of the activity and chronicity index. Total remission was obtained in 44.01% children with SRNS. The correlation of the anatomopathological aspects with the evolution is not statistically significant (p = 0.76), observing different therapeutic responses to all the analyzed histological types.

Conclusion: Almost half of NS in children are cortico resistant. Remission was obtained in 44% of cases of SRNS. Predicting the response to long-term treatment in SRNS is difficult using only renal biopsy; it is necessary to introduce genetic molecular analyses to establish a judicious therapeutic attitude.

Keywords: children; evolution; nephrotic syndrome; steroid resistance.