Associations of dietary intakes of vitamins B1 and B3 with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study

Chengyao Tang; Ehab Salah Eshak; Kokoro Shirai; Akiko Tamakoshi; Hiroyasu Iso

doi:10.1017/S0007114522001209

Associations of dietary intakes of vitamins B₁ and B₃ with risk of mortality from CVD among Japanese men and women: the Japan Collaborative Cohort study

Br J Nutr. 2022 Apr 25;129(7):1-8. doi: 10.1017/S0007114522001209. Online ahead of print.

Authors

Chengyao Tang¹, Ehab Salah Eshak^{2

3}, Kokoro Shirai¹, Akiko Tamakoshi⁴, Hiroyasu Iso¹

Affiliations

¹ Public Health, Department of Social Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
² Public Health and Community Medicine Department, Faculty of Medicine, Minia University, Minia, Egypt.
³ Advanced Clinical Epidemiology, Medical Data Science, Public Health, Graduate School of Medicine, Osaka University, Osaka, Japan.
⁴ Public Health, Department of Social Medicine, Faculty of Medicine, Hokkaido University, Hokkaido, Japan.

Abstract

The evidence on the association between B vitamins and the risk of CVD is inconclusive. We aimed to examine the association of dietary vitamins B₁ and B₃ intakes with risk of CVD mortality among 58 302 Japanese men and women aged 40-79 years participated in the Japan Collaborative Cohort (JACC) study. The Cox proportional hazard model estimated the hazard ratios (HR) and 95% CI of CVD mortality across increasing energy-adjusted quintiles of dietary vitamins B₁ and B₃ intakes. During 960 225 person-years of follow-up, we documented a total of 3371 CVD deaths. After adjustment for age, sex, and other CVD risk factors, HR of mortality from ischemic heart disease, myocardial infarction, and heart failure in the highest v. lowest vitamin B₁ intake quintiles were 0.57 (95 % CI 0·40, 0·80; P_{for trend} < 0·01), 0.56 (95 % CI 0·37, 0·82; P_{for trend} < 0·01), and 0.65 (95 % CI 0·45, 0·96; P_{for trend} = 0·13). The multivariable HR of myocardial infarction mortality in the highest v. lowest vitamin B₃ intake quintiles was 0.66 (95 % CI 0·48, 0·90; P_{for trend} = 0·02). Atendency towards a reduced risk of haemorrhagic stroke mortality was observed with a higher dietary intake of vitamin B₃ (HR: 0·74 (95 % CI 0·55, 1·01)) but not vitamin B₁. In conclusion, higher dietary intakes of vitamins B₁ and B₃ were inversely associated with mortality from ischemic heart disease and a higher dietary intake of vitamin B₁ was inversely associated with a reduced risk of mortality from heart failure among Japanese men and women.

Keywords: CVD; Cohort study; Dietary vitamin B1; Dietary vitamin B3.