Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis

Mélanie Humeau; Katia Boniface; Charles Bodet

doi:10.3389/fimmu.2022.801579

Cytokine-Mediated Crosstalk Between Keratinocytes and T Cells in Atopic Dermatitis

Front Immunol. 2022 Apr 7:13:801579. doi: 10.3389/fimmu.2022.801579. eCollection 2022.

Authors

Mélanie Humeau¹, Katia Boniface², Charles Bodet¹

Affiliations

¹ Laboratoire Inflammation Tissus Epithéliaux et Cytokines LITEC UR 15560, Université de Poitiers, Poitiers, France.
² ImmunoConcEpT, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5164, University of Bordeaux, Bordeaux, France.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by barrier dysfunction, dysregulated immune response, and dysbiosis with increased Staphylococcus aureus colonization. Infiltration of various T helper cell subsets into lesional skin and subsequent cytokine release are a hallmark of AD. Release of cytokines by both T cells and keratinocytes plays a key role in skin inflammation and drives many AD features. This review aims to discuss cytokine-mediated crosstalk between T cells and keratinocytes in AD pathogenesis and the potential impact of virulence factors produced by Staphylococcus aureus on these interactions.

Keywords: T cells; atopic dermatitis (AD); cytokines; keratinocytes; staphylococcus aureus.

Publication types

Review

MeSH terms

Cytokines
Dermatitis, Atopic*
Humans
Keratinocytes
Staphylococcal Infections* / pathology
Staphylococcus aureus

Substances

Cytokines