Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury

Yanna Chen; Huan Jing; Simin Tang; Pei Liu; Ye Cheng; Youling Fan; Hongtao Chen; Jun Zhou

doi:10.3389/fphys.2022.830924

Non-Coding RNAs in Sepsis-Associated Acute Kidney Injury

Front Physiol. 2022 Apr 8:13:830924. doi: 10.3389/fphys.2022.830924. eCollection 2022.

Authors

Yanna Chen¹, Huan Jing¹, Simin Tang¹, Pei Liu¹, Ye Cheng¹, Youling Fan^{2

3}, Hongtao Chen⁴, Jun Zhou¹

Affiliations

¹ Department of Anesthesiology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
² Department of Anesthesiology, The First People's Hospital of Kashgar, Xinjiang, China.
³ Department of Anesthesiology, The Second People's Hospital of Panyu, Guangzhou, China.
⁴ Department of Anesthesiology, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.

Abstract

Sepsis is a systemic inflammatory response caused by a severe infection that leads to multiple organ damage, including acute kidney injury (AKI). In intensive care units (ICU), the morbidity and mortality associated with sepsis-associated AKI (SA-AKI) are gradually increasing due to lack of effective and early detection, as well as proper treatment. Non-coding RNAs (ncRNAs) exert a regulatory function in gene transcription, RNA processing, post-transcriptional translation, and epigenetic regulation of gene expression. Evidence indicated that miRNAs are involved in inflammation and programmed cell death during the development of sepsis-associated AKI (SA-AKI). Moreover, lncRNAs and circRNAs appear to be an essential regulatory mechanism in SA-AKI. In this review, we summarized the molecular mechanism of ncRNAs in SA-AKI and discussed their potential in clinical diagnosis and treatment.

Keywords: acute kidney injury; circRNA; lncRNA; miRNA; sepsis.

Publication types

Review