Application Effect of ICG Fluorescence Real-Time Imaging Technology in Laparoscopic Hepatectomy

Hao Chen; Yumin Wang; Zhiguo Xie; Luyuan Zhang; Yongsheng Ge; Jihai Yu; Chuanhai Zhang; Weidong Jia; Jinliang Ma; Wenbin Liu

doi:10.3389/fonc.2022.819960

Application Effect of ICG Fluorescence Real-Time Imaging Technology in Laparoscopic Hepatectomy

Front Oncol. 2022 Apr 6:12:819960. doi: 10.3389/fonc.2022.819960. eCollection 2022.

Authors

Hao Chen¹, Yumin Wang^{2

3}, Zhiguo Xie^{1

4}, Luyuan Zhang⁵, Yongsheng Ge¹, Jihai Yu¹, Chuanhai Zhang¹, Weidong Jia¹, Jinliang Ma¹, Wenbin Liu¹

Affiliations

¹ Department of Hepatic Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
² Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
³ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, China.
⁴ Department of General Surgery, Wannan Medical College, Wuhu, China.
⁵ Department of Neurosurgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Abstract

This study aimed to evaluate the efficiency and safety of indocyanine green (ICG) fluorescence real-time imaging-guided technology in laparoscopic hepatectomy. A retrospective analysis of patients with primary liver cancer in the First Affiliated Hospital of USTC from January 2018 to October 2021, including 48 cases of fluorescence-guided laparoscopic hepatectomy (FGLH) and 60 cases of traditional laparoscopic hepatectomy (LH), was conducted. R0 resection rate, operation time, intraoperative blood loss, complications, hospital stay, and other intraoperative and postoperative indicators of the two groups were analyzed to determine the clinical feasibility and safety of ICG fluorescence real-time imaging-guided technology in laparoscopic hepatectomy. Related databases were searched for retrospective cohort studies and randomized controlled trials comparing FGLH with LH, studies were screened according to preset inclusion and exclusion criteria, literature quality was evaluated, and data were extracted. RevMan 5.3 software was used to conduct a meta-analysis on the extracted data. The results of our clinical data and meta-analysis showed that compared with LH, FGLH increased the R0 resection rate, shortened the operation time and postoperative hospital stay, and reduced blood loss and the occurrence of postoperative complications. Compared with LH, FGLH has a better application effect in laparoscopic hepatectomy, and it is worthy of promotion as it is safe and feasible.

Keywords: fluorescence imaging; hepatocellular carcinoma (HCC); indocyanine green; laparoscopic hepatectomy; meta-analysis.