Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Yue Zhang; Xinyi Zhang; Yumeng Xu; Shikun Fang; Ying Ji; Ling Lu; Wenrong Xu; Hui Qian; Zhao Feng Liang

doi:10.3389/fonc.2022.845703

Circular RNA and Its Roles in the Occurrence, Development, Diagnosis of Cancer

Front Oncol. 2022 Apr 7:12:845703. doi: 10.3389/fonc.2022.845703. eCollection 2022.

Authors

Yue Zhang¹, Xinyi Zhang¹, Yumeng Xu¹, Shikun Fang¹, Ying Ji¹, Ling Lu², Wenrong Xu¹, Hui Qian¹, Zhao Feng Liang¹

Affiliations

¹ Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China.
² Child Healthcare Department, The Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Abstract

Circular RNAs (circRNAs) are non-coding single-stranded covalently closed circular RNA, mainly produced by reverse splicing of exons of precursor mRNAs (pre-mRNAs). The characteristics of high abundance, strong specificity, and good stability of circRNAs have been discovered. A large number of studies have reported its various functions and mechanisms in biological events, such as the occurrence and development of cancer. In this review, we focus on the classification, characterization, biogenesis, functions of circRNAs, and the latest advances in cancer research. The development of circRNAs as biomarkers in cancer diagnosis and treatment also provides new ideas for studying circRNAs research.

Keywords: biogenesis; biomarkers; cancer; circRNAs; mechanisms.

Publication types

Review