Toll-like receptor 4 in COVID-19: friend or foe?

Abstract

Toll-like receptor 4, an innate immune sensor, is one of the key 'fate-deciding' regulators of immunity as well as COVID-19 immunopathogenesis. Suitable targeting of Toll-like receptor 4 appears to be an effective strategy to counteract the pandemic.

Keywords: COVID-19; SARS-CoV-2; TLR4; cytokine storm; immunotherapy.