New trends in non-pharmacological approaches for cardiovascular disease: Therapeutic ultrasound

Tianshu Liu; Jiawei Shi; Yanan Fu; Yichan Zhang; Ying Bai; Shukun He; Wenhui Deng; Qiaofeng Jin; Yihan Chen; Lingyun Fang; Lin He; Yuman Li; Yali Yang; Li Zhang; Qing Lv; Jing Wang; Mingxing Xie

doi:10.1016/j.tcm.2022.04.005

New trends in non-pharmacological approaches for cardiovascular disease: Therapeutic ultrasound

Trends Cardiovasc Med. 2023 Oct;33(7):431-440. doi: 10.1016/j.tcm.2022.04.005. Epub 2022 Apr 21.

Authors

Tianshu Liu¹, Jiawei Shi¹, Yanan Fu¹, Yichan Zhang¹, Ying Bai¹, Shukun He¹, Wenhui Deng¹, Qiaofeng Jin¹, Yihan Chen¹, Lingyun Fang¹, Lin He¹, Yuman Li¹, Yali Yang¹, Li Zhang¹, Qing Lv¹, Jing Wang², Mingxing Xie³

Affiliations

¹ Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Clinical Research Center for Medical Imaging, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China.
² Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Clinical Research Center for Medical Imaging, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: jingwang2004@hust.edu.cn.
³ Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Clinical Research Center for Medical Imaging, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China. Electronic address: xiemx@hust.edu.cn.

PMID: 35461990
DOI: 10.1016/j.tcm.2022.04.005

Abstract

Significant advances in application of therapeutic ultrasound have been reported in the past decades. Therapeutic ultrasound is an emerging non-invasive stimulation technique. This approach has shown high potential for treatment of various disease including cardiovascular disease. In this review, application principle and significance of the basic parameters of therapeutic ultrasound are summarized. The effects of therapeutic ultrasound in myocardial ischemia, heart failure, myocarditis, arrhythmias, and hypertension are explored, with key focus on the underlying mechanism. Further, the limitations and challenges of ultrasound therapy on clinical translation are evaluated to promote application of the novel strategy in cardiovascular diseases.

Keywords: Cardiovascular disease; Non-invasive stimulation; Therapeutic ultrasound.

Publication types

Review