G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions and inflammation

Cell Signal. 2022 Jul:95:110337. doi: 10.1016/j.cellsig.2022.110337. Epub 2022 Apr 21.

Abstract

G protein-coupled receptor kinase type 2 (GRK2) and β-arrestin2 are representative proteins that regulate the transduction and trafficking of G protein-coupled receptor (GPCR) signaling. The kinase GRK2 and the multifunctional scaffolding protein β-arrestin2 are key integrated signaling nodes in various biological processes, and both of them regulate cell proliferation and promote cell invasion and migration. GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer, and inflammatory diseases. This review summarizes the roles of GRK2/β-arrestin2 in immune cell function and focuses on the pathological implications of GRK2/β-arrestin2 in various inflammatory diseases.

Keywords: Cell signaling; GRK2; Immune cells; Inflammation; β-arrestin2.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • G-Protein-Coupled Receptor Kinase 2* / metabolism
  • Humans
  • Inflammation
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction* / physiology
  • beta-Arrestin 1 / metabolism
  • beta-Arrestin 2 / metabolism
  • beta-Arrestins / metabolism

Substances

  • Receptors, G-Protein-Coupled
  • beta-Arrestin 1
  • beta-Arrestin 2
  • beta-Arrestins
  • G-Protein-Coupled Receptor Kinase 2