Air pollution: A culprit of lung cancer

Yueguang Xue; Liuxiang Wang; Yiming Zhang; Yuliang Zhao; Ying Liu

doi:10.1016/j.jhazmat.2022.128937

Air pollution: A culprit of lung cancer

J Hazard Mater. 2022 Jul 15:434:128937. doi: 10.1016/j.jhazmat.2022.128937. Epub 2022 Apr 15.

Authors

Yueguang Xue¹, Liuxiang Wang¹, Yiming Zhang², Yuliang Zhao³, Ying Liu⁴

Affiliations

¹ School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nano safety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; Henan Institute of advanced technology, Zhengzhou University, Zhengzhou 450052, PR China.
² CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nano safety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; Henan Institute of advanced technology, Zhengzhou University, Zhengzhou 450052, PR China.
³ CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nano safety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; GBA National Institute for Nanotechnology Innovation, Guangzhou, Guangdong 510700, PR China. Electronic address: zhaoyl@nanoctr.cn.
⁴ School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, PR China; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nano safety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, PR China; GBA National Institute for Nanotechnology Innovation, Guangzhou, Guangdong 510700, PR China. Electronic address: liuy@nanoctr.cn.

PMID: 35452993
DOI: 10.1016/j.jhazmat.2022.128937

Abstract

Air pollution is a global health problem, especially in the context of rapid economic development and the expansion of urbanization. Herein, we discuss the harmful effects of outdoor and indoor pollution on the lungs. Ambient particulate matters (PMs) from industrial and vehicle exhausts is associated with lung cancer. Workers exposed to asbestos, polycyclic aromatic hydrocarbons (PAHs), and toxic metals are also likely to develop lung cancer. Indoors, cooking fumes, second-hand smoke, and radioactive products from house decoration materials play roles in the development of lung cancer. Bacteria and viruses can also be detrimental to health and are important risk factors in lung inflammation and cancer. Specific effects of lung cancer caused by air pollution are discussed in detail, including inflammation, DNA damage, and epigenetic regulation. In addition, advanced materials for personal protection, as well as the current government policies to prevent air pollution, are summarized. This review provides a basis for future research on the relationship between lung cancer and air pollution.

Keywords: Air pollution; Health; Lung cancer; Pathogenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Air Pollutants* / analysis
Air Pollution* / adverse effects
Air Pollution, Indoor* / analysis
Epigenesis, Genetic
Humans
Lung Neoplasms* / chemically induced
Particulate Matter / analysis
Particulate Matter / toxicity
Polycyclic Aromatic Hydrocarbons* / analysis
Polycyclic Aromatic Hydrocarbons* / toxicity

Substances

Air Pollutants
Particulate Matter
Polycyclic Aromatic Hydrocarbons