Engineered nasal dry powder for the encapsulation of bioactive compounds

Alberto Baldelli; Mohammed A Boraey; Hale Oguzlu; Aylin Cidem; Athenea Pascual Rodriguez; Hui Xin Ong; Feng Jiang; Mattia Bacca; Andrew Thamboo; Daniela Traini; Anubhav Pratap-Singh

doi:10.1016/j.drudis.2022.04.012

Engineered nasal dry powder for the encapsulation of bioactive compounds

Drug Discov Today. 2022 Aug;27(8):2300-2308. doi: 10.1016/j.drudis.2022.04.012. Epub 2022 Apr 19.

Authors

Affiliations

¹ Faculty of Land and Food Systems, The University of British Columbia, BC, Canada. Electronic address: baldelli@mail.ubc.ca.
² Mechanical Power Engineering Department, Zagazig University, Zagazig 44519, Egypt; Smart Engineering Systems Research Center (SESC), Nile University, Giza 12588, Egypt. Electronic address: boraey@ualberta.ca.
³ Department of Forestry, University of British Columbia, BC, Canada.
⁴ Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia.
⁵ Department of Surgery, The University of British Columbia, BC, Canada.
⁶ Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW 2037, Australia; Department of Biomedical Sciences, Faculty of Medicine, Health and Human Sciences, Macquarie University, NSW 2109, Australia.
⁷ Department of Mechanical Engineering, University of British Columbia, BC, Canada.
⁸ Faculty of Land and Food Systems, The University of British Columbia, BC, Canada.

PMID: 35452791
DOI: 10.1016/j.drudis.2022.04.012

Abstract

In this review, we present the potential of nasal dry powders to deliver stable bioactive compounds and their manufacture using spray-drying (SD) techniques to achieve encapsulation. We also review currently approved and experimental excipients used for powder manufacturing for specific target drugs. Polymers, sugars, and amino acids are recommended for specific actions, such as mucoadhesive interactions, to increase residence time on the nasal mucosa; for example, high-molecular weight polymers, such as hydroxypropyl methylcellulose, or mannitol, which protect the bioactive compounds, increase their stability, and enhance drug absorption in the nasal mucosa; and leucine, which promotes particle formation and improves aerosol performance.

Keywords: Dry powder; Nasal delivery; Particle engineering; Spraying techniques.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Inhalation
Drug Compounding
Dry Powder Inhalers*
Particle Size
Polymers*
Powders / chemistry

Substances

Polymers
Powders