CLP1-dependent premature transcription termination opposes neurodegeneration

Michal R Gdula; Magda Kopczyńska; Upasana Saha; Kinga Kamieniarz-Gdula

doi:10.1016/j.neuron.2022.03.012

CLP1-dependent premature transcription termination opposes neurodegeneration

Neuron. 2022 Apr 20;110(8):1277-1280. doi: 10.1016/j.neuron.2022.03.012.

Authors

Michal R Gdula¹, Magda Kopczyńska², Upasana Saha², Kinga Kamieniarz-Gdula³

Affiliations

¹ Center for Advanced Technology, Adam Mickiewicz University, Uniwersytetu Poznanskiego 10, 61-614 Poznań, Poland; Department of Gene Expression, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.
² Center for Advanced Technology, Adam Mickiewicz University, Uniwersytetu Poznanskiego 10, 61-614 Poznań, Poland; Department of Molecular and Cellular Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland.
³ Center for Advanced Technology, Adam Mickiewicz University, Uniwersytetu Poznanskiego 10, 61-614 Poznań, Poland; Department of Molecular and Cellular Biology, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznań, Poland. Electronic address: kinga.kamieniarz-gdula@amu.edu.pl.

PMID: 35447096
DOI: 10.1016/j.neuron.2022.03.012

Abstract

Usage of alternative mRNA 3' ends has profound functional consequences, particularly in the nervous system. In this issue of Neuron, LaForce et al. (2022) dissect the effect of CLP1 on mRNA 3' end diversity in motor neuron models of neurodegeneration.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Motor Neurons*
RNA, Messenger / genetics
Transcription, Genetic*

Substances

RNA, Messenger