The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases

Binyue Xu; Lu Chen; Yu Zhan; Karl Nelson S Marquez; Lvjia Zhuo; Shasha Qi; Jinyu Zhu; Ying He; Xudong Chen; Hao Zhang; Yingying Shen; Gongxing Chen; Jianzhong Gu; Yong Guo; Shuiping Liu; Tian Xie

doi:10.3389/fcell.2022.857919

The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases

Front Cell Dev Biol. 2022 Apr 4:10:857919. doi: 10.3389/fcell.2022.857919. eCollection 2022.

Authors

Binyue Xu¹, Lu Chen^{2

3}, Yu Zhan¹, Karl Nelson S Marquez⁴, Lvjia Zhuo^{2

3}, Shasha Qi^{2

3}, Jinyu Zhu^{2

3}, Ying He^{2

3}, Xudong Chen^{2

3}, Hao Zhang^{2

3}, Yingying Shen¹, Gongxing Chen^{2

3}, Jianzhong Gu¹, Yong Guo¹, Shuiping Liu^{2

3}, Tian Xie^{2

3}

Affiliations

¹ Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
² School of Pharmacy, Hangzhou Normal University, Hangzhou, China.
³ Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, China.
⁴ Clinical Medicine, Tongji Medical College, Huazhong University of Science and Technology, Hankou, China.

Abstract

In recent years, fatty acid binding protein 5 (FABP5), also known as fatty acid transporter, has been widely researched with the help of modern genetic technology. Emerging evidence suggests its critical role in regulating lipid transport, homeostasis, and metabolism. Its involvement in the pathogenesis of various diseases such as metabolic syndrome, skin diseases, cancer, and neurological diseases is the key to understanding the true nature of the protein. This makes FABP5 be a promising component for numerous clinical applications. This review has summarized the most recent advances in the research of FABP5 in modulating cellular processes, providing an in-depth analysis of the protein's biological properties, biological functions, and mechanisms involved in various diseases. In addition, we have discussed the possibility of using FABP5 as a new diagnostic biomarker and therapeutic target for human diseases, shedding light on challenges facing future research.

Keywords: FABP5; cell differentiation; immune response; lipid homeostasis; lipid metabolism; tumorigenesis.

Publication types

Review