Molecular Patho-mechanisms of cervical cancer (MMP1)

Iwan Kurnia; Syahrul Rauf; Mochammad Hatta; Sharvianty Arifuddin; Yudi Maulana Hidayat; Rosdiana Natzir; Cahyo Kaelan; Agussalim Bukhari; Nugraha Utama Pelupessy; Ilham Jaya Patelonggi

doi:10.1016/j.amsu.2022.103415

Molecular Patho-mechanisms of cervical cancer (MMP1)

Ann Med Surg (Lond). 2022 Mar 31:77:103415. doi: 10.1016/j.amsu.2022.103415. eCollection 2022 May.

Affiliations

¹ Department of Obstetrics and Gynaecology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
² Department of Molecular Biology and Immunology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
³ Department of Obstetrics and Gynaecology, Faculty of Medicine Universitas Padjajaran, Bandung, Indonesia.
⁴ Department of Biochemistry, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
⁵ Department of Anatomical Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
⁶ Department of Clinical Nutrition, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.
⁷ Department of Physiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Abstract

Cervical cancer mostly caused by Human Papilloma Virus. Staging and therapy have been extensively studied, and highly correlated with the cellular development of oncogenesis. Mutation was caused by E6 and E7 oncoprotein, also inactivation of 2 tumor suppressor factors (pRB and p53). P53 also regulated MMP1, which dysregulation of MMP transcription would promote tumor metastasis, because of its role in extracellular matrix degradation in tumor invasion. Clinical staging of Cervical Cancer was based on Federation International of Gynaecology and Obstetrics (FIGO) classification from 2018. Management was divided into Surgery, Radiotherapy, and Chemotherapy.

Publication types

Review