T2 mapping for knee cartilage degeneration in young patients with mild symptoms

Huiyu Zhao; Hongqiu Li; Shuo Liang; Xinyue Wang; Feng Yang

doi:10.1186/s12880-022-00799-1

T2 mapping for knee cartilage degeneration in young patients with mild symptoms

BMC Med Imaging. 2022 Apr 18;22(1):72. doi: 10.1186/s12880-022-00799-1.

Authors

Huiyu Zhao¹, Hongqiu Li², Shuo Liang¹, Xinyue Wang¹, Feng Yang³

Affiliations

¹ Department of Radiology, Central Hospital Affiliated to Shenyang Medical College, No. 5, South Seven West Road, Tiexi District, Shenyang, 110024, Liaoning, China.
² The 2Th Department of Orthopedic Surgery, Central Hospital Affiliated to Shenyang Medical College, No. 5, South Seven West Road, Tiexi District, Shenyang, 110024, Liaoning, China.
³ Department of Radiology, Central Hospital Affiliated to Shenyang Medical College, No. 5, South Seven West Road, Tiexi District, Shenyang, 110024, Liaoning, China. summit-windy@163.com.

Abstract

Background: We aimed to analyze the distribution of knee cartilage degeneration in young patients with mild symptoms using quantitative magnetic resonance imaging (MRI) T2 mapping.

Materials and methods: This study included sixty six patients (case group) and twenty eight healthy volunteers (control group). The participants underwent 3.0 T conventional MRI plus a multi-echo sequence. The cartilage of each participant was divided into twenty eight subregions. We then calculated the T2 mean values and standard deviation or median and quartile range for each subregion according to whether the normal distribution was satisfied. Besides, we employed Kruskal-Wallis test to determine the statistical differences of each subregion in the control group while the Mann-Whitney U test was used to define the statistical difference between the case group and the control group and between the control group and subjects aged less than or equal to 35 years in the case group.

Results: In the case group, age of 30 male patients was 31.5 ± 9.3 and age of 36 female patients was 35.7 ± 8.3. In the two groups, the superficial central lateral femoral region exhibited relatively high T2 values (control/case group: 49.6 ± 2.7/55.9 ± 8.8), and the deep medial patellar region exhibited relatively low T2 values (control/case group: 34.2 ± 1.3/33.5(32.2, 35.5)). Comparison of the T2 values between the case and the control group demonstrated a statistically significant increase in nine subregions (P₁ < 0.05) and there were five subregions in the case group with age ≤ 35 years (P₂ < 0.05). In particular, the p-values for four subregions of the patellofemoral joint were all less than 0.05 (P₁ = 0.002, 0.015, 0.036, 0.005).

Conclusion: T2 values of patients were significantly different with values of healthy groups, especially in the superficial cartilage of the patellofemoral joint. It made T2 mapping helpful to early identify patients with knee cartilage degeneration.

Keywords: Knee cartilage degeneration; Mild symptoms; T2 mapping; Young patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cartilage, Articular* / diagnostic imaging
Cartilage, Articular* / pathology
Female
Healthy Volunteers
Humans
Knee Joint / diagnostic imaging
Magnetic Resonance Imaging / methods
Male