Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions

Tiantian Ma; Feng Zhang; Yaqing Wang; Zhiheng Xu

doi:10.1016/j.jgg.2022.04.001

Molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions

J Genet Genomics. 2022 Jun;49(6):519-522. doi: 10.1016/j.jgg.2022.04.001. Epub 2022 Apr 15.

Authors

Tiantian Ma¹, Feng Zhang¹, Yaqing Wang¹, Zhiheng Xu²

Affiliations

¹ Center for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
² Center for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address: zhxu@genetics.ac.cn.

PMID: 35436610
DOI: 10.1016/j.jgg.2022.04.001

Abstract

Coat protein complex II (COPII)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum (ER) to different destinations. cTAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPII carrier and cargo trafficking through direct or indirect interaction with COPII components. cTAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions.

Keywords: COPII; Cargo secretion; ER; cTAGE5/MEA6.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Transport
COP-Coated Vesicles* / metabolism
Endoplasmic Reticulum* / metabolism
Golgi Apparatus / metabolism
Protein Transport