An evolving understanding of sorting signals for endosomal retrieval

Xin Yong; Lejiao Mao; Matthew N J Seaman; Da Jia

doi:10.1016/j.isci.2022.104254

An evolving understanding of sorting signals for endosomal retrieval

iScience. 2022 May 20;25(5):104254. doi: 10.1016/j.isci.2022.104254. Epub 2022 Apr 13.

Authors

Xin Yong¹, Lejiao Mao¹, Matthew N J Seaman², Da Jia¹

Affiliations

¹ Key Laboratory of Birth Defects and Related Diseases of Women and Children, Department of Paediatrics, West China Second University Hospital, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
² Cambridge Institute for Medical Research, University of Cambridge, The Keith Peters Building, Cambridge Biomedical Campus, CB2 0XY, UK.

Abstract

Complex mechanisms govern the sorting of membrane (cargo) proteins at endosomes to ensure that protein localization to the post-Golgi endomembrane system is accurately maintained. Endosomal retrieval complexes mediate sorting by recognizing specific motifs and signals in the cytoplasmic domains of cargo proteins transiting through endosomes. In this review, the recent progress in understanding the molecular mechanisms of how the retromer complex, in conjunction with sorting nexin (SNX) proteins, operates in cargo recognition and sorting is discussed. New data revealing the importance of different SNX proteins and detailing how post-translational modifications can modulate cargo sorting to respond to changes in the environment are highlighted along with the key role that endosomal protein sorting plays in SARS-CoV-2 infection.

Keywords: Biological sciences; Cell biology; Functional aspects of cell biology.

Publication types

Review