Ambient air pollution during pregnancy and cardiometabolic biomarkers in cord blood

Chloe Friedman; Dana Dabelea; Lizan D Bloemsma; Deborah S K Thomas; Jennifer L Peel; John L Adgate; Sheryl Magzamen; Sheena E Martenies; William B Allshouse; Anne P Starling

doi:10.1097/EE9.0000000000000203

Ambient air pollution during pregnancy and cardiometabolic biomarkers in cord blood

Environ Epidemiol. 2022 Mar 22;6(2):e203. doi: 10.1097/EE9.0000000000000203. eCollection 2022 Apr.

Authors

Chloe Friedman^{1

2}, Dana Dabelea^{1

2

3}, Lizan D Bloemsma^{1

2}, Deborah S K Thomas⁴, Jennifer L Peel⁵, John L Adgate⁶, Sheryl Magzamen^{6

7}, Sheena E Martenies⁵, William B Allshouse⁶, Anne P Starling^{1

2

8}

Affiliations

¹ Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
² Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
³ Department of Pediatrics, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
⁴ Department of Geography and Earth Sciences, University of North Carolina at Charlotte, Charlotte, North Carolina.
⁵ Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado.
⁶ Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado.
⁷ Department of Epidemiology, Colorado School of Public Health, Colorado State University, Fort Collins, Colorado.
⁸ Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.

Abstract

Prenatal air pollution exposure has been associated with adverse childhood cardiometabolic outcomes. It is unknown whether evidence of metabolic disruption associated with air pollution is identifiable at birth. We examined exposure to prenatal ambient air pollution and cord blood cardiometabolic biomarkers among 812 mother-infant pairs in the Healthy Start study.

Methods: Using inverse-distance-weighted interpolation of ambient concentrations obtained from stationary monitors, we estimated daily particulate matter ≤2.5 micrometers (PM_2.5) and ozone (O₃) concentrations at participant residences. Daily estimates were averaged by trimester, full-pregnancy, and the 7 and 30 days prior to delivery. Associations of air pollution with the following cord blood biomarkers were estimated via multivariable linear regression: glucose, insulin, glucose/insulin ratio (GIR), leptin, high-density lipoprotein (HDL) cholesterol, non-HDL cholesterol, free fatty acids, and triglycerides.

Results: In this Denver-based cohort, PM_2.5 concentrations were lower than in many US urban areas, but O₃ concentrations regularly exceeded federal air quality standards. Higher O₃ concentrations during pregnancy were consistently associated with higher insulin and lower GIR in cord blood. For example, an interquartile range increase in full pregnancy O₃ (6.3 parts per billion [ppb]) was associated with 0.13 log-µIU/ml (95% confidence interval [CI] = 0.04, 0.22) higher cord blood insulin, after adjusting for PM_2.5 and other confounders. We found positive, but generally nonsignificant, associations between PM_2.5 and leptin and isolated associations between pollutants during certain exposure periods and lipids.

Conclusions: In this cohort with moderately high O₃ exposure, prenatal concentrations of O₃ were positively associated with cord blood insulin. Future studies should examine the implications for offspring long-term health.

Keywords: Air pollution; Lipids; Metabolism; Neonate; Prenatal exposure.

Abstract

Grants and funding