The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer

Zeng-Yao Liu; Qing-Chun Jia; Wen Wang; Yu-Xi Liu; Rui-Tao Wang; Jia-Yu Li

doi:10.1155/2022/9012063

The Association between Platelet Glycocalicin and High Microsatellite Instability in Colorectal Cancer

Gastroenterol Res Pract. 2022 Apr 7:2022:9012063. doi: 10.1155/2022/9012063. eCollection 2022.

Authors

Zeng-Yao Liu^{1

2}, Qing-Chun Jia¹, Wen Wang¹, Yu-Xi Liu¹, Rui-Tao Wang¹, Jia-Yu Li³

Affiliations

¹ Department of Internal Medicine, Harbin Medical University Cancer Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, China.
² Department of Interventional Medicine, The First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China.
³ Institute of Intensive Care Medicine, Heilongjiang Academy of Medical Science, Harbin, Heilongjiang 150081, China.

Abstract

Background: Elevated platelet volume is the risk factor for the development and poor overall survival of colorectal cancer (CRC) patients. Both microsatellite status and platelet glycoprotein Ibα (GPIbα) are related to platelet volume in CRC patients. This study aimed to investigate platelet GPIbα ectodomain (termed glycocalicin) levels among CRC patients and the association between the glycocalicin levels and microsatellite status in CRC.

Methods: The clinical and laboratory data of 430 CRC patients between January 2018 and December 2018 in Harbin Medical University Cancer Hospital were collected. The microsatellite status was determined with a polymerase chain reaction. The participants were separated into high microsatellite instability (MSI-H) and microsatellite stable (MSS) groups according to microsatellite status. The glycocalicin levels were measured with an enzyme-linked immunosorbent assay, and the cut-off point was determined with the receiver-operating characteristics curve. The clinical and pathological characteristics were collected via electronic medical records. Logistic regression was used to explore the association between glycocalicin and microsatellite status.

Results: Among the 430 CRC patients enrolled, 64 patients (14.9%) were identified as MSI-H and others as MSS CRC. Glycocalicin levels were significantly reduced in patients with MSI-H than those with MSS. After controlling for potential confounders, logistic regression analysis revealed that glycocalicin levels were independently associated with MSI-H CRC.

Conclusions: Reduced glycocalicin levels are associated with the MSI-H subtype of CRC. Further research is needed to elucidate the mechanisms of the association between glycocalicin and MSI-H in CRC patients.