The impact of zinc on the molecular signaling pathways in the diabetes disease

Keyvan Asghari; Zahra Shargh; Sina Fatehfar; Leila Chodari; Parsa Sameei

doi:10.1016/j.jtemb.2022.126985

The impact of zinc on the molecular signaling pathways in the diabetes disease

J Trace Elem Med Biol. 2022 Jul:72:126985. doi: 10.1016/j.jtemb.2022.126985. Epub 2022 Apr 11.

Authors

Keyvan Asghari¹, Zahra Shargh¹, Sina Fatehfar¹, Leila Chodari², Parsa Sameei³

Affiliations

¹ Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
² Neurophysiology Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran; Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: chodari.l@umsu.com.
³ Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: parsa.sameei@gmail.com.

PMID: 35429747
DOI: 10.1016/j.jtemb.2022.126985

Abstract

Since there's been an upsurge in people with diabetes or pre-diabetes conditions, many studies have been conducted to evaluate approaches for reducing the complications of diabetes. One of the most common therapeutic elements suggested for this purpose is zinc (Zn). Zn has long been shown to positively improve complications of both type 1 and type 2 diabetes. This review aims to provide comprehensive information about the influence of Zn on the various signaling pathways in multiple tissues with diabetic conditions, with great attention to the treatment period and effective dose of Zn.

Keywords: Diabetes; Molecular signaling pathways; Zinc.

Publication types

Review

MeSH terms

Diabetes Mellitus, Type 2* / drug therapy
Diabetes Mellitus, Type 2* / metabolism
Humans
Signal Transduction
Zinc* / metabolism

Substances

Zinc