Objective: The clinical effects of the nourishing Yin and tonifying Yang sequential method with Femoston was explored in treating circadian disorder with premature ovarian insufficiency (POI).
Method: We enrolled 600 patients with circadian disorder and POI in a prospective study and divided the patients into 2 groups: an experimental and a control group. Both groups were treated with Femoston and the experimental group also received nourishing Yin and tonifying Yang sequential method. We observed the overall response rate, Kupperman Index, number of adverse events, and the levels of prostaglandin E2 (E2), follicle-stimulating hormone (FSH), luteinizing hormone (LH), total cholesterol (TC), triglycerices (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), as well as peak systolic velocity (PSV), pulsatility index (PI), resistance index (RI), maximum ovarian diameter (MOD) and antral follicle count (AFC).
Results: The experimental group also exhibited elevated TC, TG, LDL-C, MOD and AFC after treatment, whereas the control group did not. Compared with the control group, the experimental group had a higher overall response rate, E2, FSH, LH, HDL-C, PSV, MOD, AFC, a lower Kupperman Index, TC, TG, LDL-C, PI, RI and number of adverse events.
Conclusions: In patients with circadian disorder with POI, the nourishing Yin and tonifying Yang sequential method with Femoston improved ovarian function, blood supply to the ovaries and sex hormone levels and lowered blood lipids with acceptable safety parameters.