Rhabdastrenones A-D from the sponge Rhabdastrella globostellata

Do Thi Trang; Dan Thi Thuy Hang; Duong Thi Dung; Nguyen Thi Cuc; Pham Hai Yen; Phan Thi Thanh Huong; Le Thi Huyen; Nguyen Thi Mai; Nguyen Xuan Nhiem; Bui Huu Tai; Phan Van Kiem

doi:10.1039/d2ra01674e

Rhabdastrenones A-D from the sponge Rhabdastrella globostellata

RSC Adv. 2022 Apr 6;12(17):10646-10652. doi: 10.1039/d2ra01674e. eCollection 2022 Mar 31.

Authors

Do Thi Trang^{1

2}, Dan Thi Thuy Hang¹, Duong Thi Dung¹, Nguyen Thi Cuc¹, Pham Hai Yen¹, Phan Thi Thanh Huong¹, Le Thi Huyen³, Nguyen Thi Mai⁴, Nguyen Xuan Nhiem^{1

2}, Bui Huu Tai^{1

2}, Phan Van Kiem^{1

2}

Affiliations

¹ Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam bhtaiich@gmail.com phankiem@yahoo.com.
² Graduate University of Science and Technology, VAST 18 Hoang Quoc Viet, Cau Giay Hanoi Vietnam.
³ VNU University of Science, Vietnam National University, Hanoi 334 Nguyen Trai, Thanh Xuan Hanoi Vietnam.
⁴ University of Transport and Communications 3 Cau Giay, Dong Da Hanoi Vietnam.

Abstract

Three new isomalabaricanes (1-3), a new α-pyrone derivative (4), together with four known isomalabaricane analogs rhabdastrellin G (5), isogeoditin A (6), stelliferin A (7), and (13E)-isogeoditin A (8) were isolated from the marine sponge Rhabdastrella globostellata. Their chemical structures were determined by HR-ESI-MS, 1D and 2D-NMR spectroscopic data analysis. The absolute configurations were identified by Mo₂(OAc)₄ induced ECD spectra and TD-DFT theoretical calculated ECD spectra. Compound 6 exhibited weak cytotoxic effects against HepG2 and SKMel2 cell lines with the IC₅₀ values of 7.53 ± 0.70 and 9.93 ± 0.95 μM, respectively.