A multi pathway coupled domino strategy: I2/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

Yishou Wang; Shichen Li; Xinfeng Wang; Yiming Yao; Lei Feng; Chen Ma

doi:10.1039/d1ra07438e

A multi pathway coupled domino strategy: I₂/TBHP-promoted synthesis of imidazopyridines and thiazoles via sp³, sp² and sp C-H functionalization

RSC Adv. 2022 Feb 17;12(10):5919-5927. doi: 10.1039/d1ra07438e. eCollection 2022 Feb 16.

Authors

Yishou Wang¹, Shichen Li¹, Xinfeng Wang¹, Yiming Yao¹, Lei Feng¹, Chen Ma¹

Affiliation

¹ School of Chemistry and Chemical Engineering, Shandong University Jinan 250100 P. R. China chenma@sdu.edu.cn.

Abstract

I₂/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I₂/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.