Schizophrenia, Bipolar Disorder and Pre-Attentional Inhibitory Deficits

Premysl Vlcek; Petr Bob

doi:10.2147/NDT.S352157

Schizophrenia, Bipolar Disorder and Pre-Attentional Inhibitory Deficits

Neuropsychiatr Dis Treat. 2022 Apr 8:18:821-827. doi: 10.2147/NDT.S352157. eCollection 2022.

Authors

Premysl Vlcek^{1

2}, Petr Bob³

Affiliations

¹ National Institute of Mental Health, Klecany, Czech Republic.
² Third Faculty of Medicine, Charles University, Prague, Czech Republic.
³ Center for Neuropsychiatric Research of Traumatic Stress, Department of Psychiatry and UHSL, First Faculty of Medicine, Department of Psychiatry, & Faculty of Medicine Pilsen, Charles University, Prague, Czech Republic.

Abstract

According to recent findings schizophrenia and bipolar disorder as separate disease entities manifest similarities in neuropsychological functioning. Typical disturbances in both disorders are related to sensory gating deficits characterized by decreased inhibitory functions in responses to various insignificant perceptual signals which are experimentally tested by event related potentials (ERP) and measured P50 wave. In this context, recent findings implicate that disrupted binding and disintegration of consciousness in schizophrenia and bipolar disorder that are related to inhibitory deficits reflected in P50 response may explain similarities in psychotic disturbances in both disorders. With this aim, this review summarizes literature about P50 in both schizophrenia and bipolar disorder.

Keywords: P50; bipolar disorder; event related potentials; inhibition; neural synchrony; schizophrenia.

Publication types

Review