Neutrophils flash their GLUTs to beat back detestable fungi

Samantha L Avina; Darin L Wiesner

doi:10.1016/j.chom.2022.03.027

Neutrophils flash their GLUTs to beat back detestable fungi

Cell Host Microbe. 2022 Apr 13;30(4):415-417. doi: 10.1016/j.chom.2022.03.027.

Authors

Samantha L Avina¹, Darin L Wiesner²

Affiliations

¹ Public Health Research Institute, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA.
² Center for Immunity and Inflammation, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA; Department of Medicine, New Jersey Medical School, Rutgers-The State University of New Jersey, Newark, NJ, USA. Electronic address: dw667@njms.rutgers.edu.

PMID: 35421332
DOI: 10.1016/j.chom.2022.03.027

Abstract

Neutrophils enforce frontline immunity to fungal infection. Potent neutrophil effector functions require vast amounts of cytosolic glucose. Li et al. describe how neutrophils, upon interaction with Candida albicans, modulate the new synthesis and membrane localization of Glucose Transporter 1 (GLUT1) to facilitate glucose entry and meet neutrophils' metabolic needs.

Publication types

Comment

MeSH terms

Candida albicans*
Glucose
Neutrophils*

Substances

Glucose