The Role of the Gut Microbiota in the Development of Ischemic Stroke

Jinchen Wang; Hongfei Zhang; Jianying He; Xiaoxing Xiong

doi:10.3389/fimmu.2022.845243

The Role of the Gut Microbiota in the Development of Ischemic Stroke

Front Immunol. 2022 Mar 28:13:845243. doi: 10.3389/fimmu.2022.845243. eCollection 2022.

Authors

Jinchen Wang^{1

2}, Hongfei Zhang¹, Jianying He³, Xiaoxing Xiong²

Affiliations

¹ Department of Anesthesiology, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
² Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
³ Department of Orthopedic, JiangXi Provinvcial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China.

Abstract

An increasing number of studies have focused on the gut microbiota and its relationship with various neurological diseases. The gut microbiota can affect the metabolic status of the body, in addition to having an important impact on blood pressure, blood glucose, and atherosclerosis, all of which are risk factors for ischemic stroke. In this review, we summarized studies that included the physiological function of the gut microbiota and gut microbiota disorders related to the central nervous system, thus providing novel ideas for the prevention and treatment of ischemic stroke.

Keywords: fecal microbiota transplantation; gut microbiota; gut-brain axis communication; ischemic stroke; neuro inflammation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Central Nervous System
Gastrointestinal Microbiome* / physiology
Humans
Ischemic Stroke* / etiology
Nervous System Diseases*
Risk Factors