Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Zhuo-Fen Deng; Irina Bakunina; Hua Yu; Jaehong Han; Alexander Dömling; Maria-José U Ferreira; Jian-Ye Zhang

doi:10.3389/fphar.2022.815603

Research Progress on Natural Diterpenoids in Reversing Multidrug Resistance

Front Pharmacol. 2022 Mar 28:13:815603. doi: 10.3389/fphar.2022.815603. eCollection 2022.

Authors

Zhuo-Fen Deng¹, Irina Bakunina², Hua Yu³, Jaehong Han⁴, Alexander Dömling⁵, Maria-José U Ferreira⁶, Jian-Ye Zhang¹

Affiliations

¹ Key Laboratory of Molecular Target & Clinical Pharmacology, The State & NMPA Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
² G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
³ Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, China.
⁴ Metalloenzyme Research Group and Department of Plant Science and Technology, Chung-Ang University, Anseong, Korea.
⁵ Department of Pharmacy, University of Groningen, Groningen, Netherlands.
⁶ Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisboa, Portugal.

Abstract

Multidrug resistance (MDR) is one of the main impediments in successful chemotherapy in cancer treatment. Overexpression of ATP-binding cassette (ABC) transporter proteins is one of the most important mechanisms of MDR. Natural products have their unique advantages in reversing MDR, among which diterpenoids have attracted great attention of the researchers around the world. This review article summarizes and discusses the research progress on diterpenoids in reversing MDR.

Keywords: cancer; chemotherapy; diterpenoids; multidrug resistance; natural products.

Publication types

Review