Seven sesquiterpenes including four eremophilanes (1-4) and three cadinenes (5-7), were isolated from the heartwood of Syringa oblata Lindl. Among them, three new eremophilane-type sesquiterpenes were identified and named oblatanoids A-C (1-3), respectively. Their structures were established by extensive analyses of spectroscopic methods, and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. All these new compounds were evaluated for protective effects against hypoxia-induced injury on H9c2 cells, and 1-3 exhibited significantly protective activities toward H9c2 cells in vitro.
Keywords: Syringa oblata; cardioprotective effect; oblatanoids A-C; sesquiterpene.
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