An unexpected role for PD-L1 in front-rear polarization and directional migration

J Cell Biol. 2022 May 2;221(5):e202203137. doi: 10.1083/jcb.202203137. Epub 2022 Apr 13.

Abstract

Programmed cell death-ligand 1 (PD-L1)-mediated T cell inhibition through PD-1 is a key checkpoint frequently exploited by tumors to evade immunity. In this issue, Wang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202108083) reveal an unexpected role for PD-L1 in promoting tumor cell front-rear polarity and directionally persistent cell migration, independently of PD-1.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • B7-H1 Antigen* / genetics
  • Cell Movement
  • Humans
  • Neoplasms*
  • Programmed Cell Death 1 Receptor
  • T-Lymphocytes
  • Tumor Escape

Substances

  • B7-H1 Antigen
  • Programmed Cell Death 1 Receptor