Small molecule inhibitors from organoid-based drug screen induce concurrent apoptosis and gasdermin E-dependent pyroptosis in colorectal cancer

Yuchen Zhang; Zhuoqing Xu; Wenqing Feng; Han Gao; Zifeng Xu; Yiming Miao; Wenchang Li; Fangqian Chen; Zeping Lv; Jianting Huo; Abudumaimaitijiang Tuersun; Wangyi Liu; Yaping Zong; Xiaohui Shen; Jingkun Zhao; Aiguo Lu

doi:10.1002/ctm2.812

Small molecule inhibitors from organoid-based drug screen induce concurrent apoptosis and gasdermin E-dependent pyroptosis in colorectal cancer

Clin Transl Med. 2022 Apr;12(4):e812. doi: 10.1002/ctm2.812.

Authors

Yuchen Zhang^{1

2}, Zhuoqing Xu^{1

2}, Wenqing Feng^{1

2}, Han Gao^{1

2}, Zifeng Xu^{1

2}, Yiming Miao^{1

2}, Wenchang Li³, Fangqian Chen^{1

2}, Zeping Lv^{1

2}, Jianting Huo^{1

2}, Abudumaimaitijiang Tuersun^{1

2}, Wangyi Liu^{1

2}, Yaping Zong^{1

2}, Xiaohui Shen^{1

2}, Jingkun Zhao^{1

2}, Aiguo Lu^{1

2}

Affiliations

¹ Department of General Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
² Shanghai Minimally Invasive Surgery Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
³ Department of Radiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis
Colorectal Neoplasms* / drug therapy
Humans
Organoids
Phosphate-Binding Proteins
Pyroptosis*

Substances

Phosphate-Binding Proteins