Two new α-pyrone-containing polyketides isolated from the fungus Aspergillus aureoterreus

Beiping Zhou; Qingyi Tong; Yi Zang; Honghui Zhu

doi:10.1080/14786419.2022.2062753

Two new α-pyrone-containing polyketides isolated from the fungus Aspergillus aureoterreus

Nat Prod Res. 2023 Oct-Nov;37(19):3207-3213. doi: 10.1080/14786419.2022.2062753. Epub 2022 Apr 12.

Authors

Beiping Zhou^{1

2}, Qingyi Tong³, Yi Zang², Honghui Zhu^{1

2}

Affiliations

¹ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China.
² Key Laboratory of Agricultural Microbiomics and Precision Application-Ministry of Agriculture and Rural Affairs, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Guangdong Microbial Culture Center (GDMCC), Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.
³ School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

PMID: 35412412
DOI: 10.1080/14786419.2022.2062753

Abstract

Two undescribed α-pyrone-containing polyketide derivatives designated aurovertins V (1) and W (2), and a known analogue (3), were isolated from the fungus Aspergillus aureoterreus. Their structures including the absolute configuration were elucidated on the basis of extensive spectroscopic methods and theoretical ECD calculation. Compound 1 is the first example of aurovertins with a 7R configuration, whereas 2 comprises a S configuration for C-6 and a Z geometry of the double bond Δ⁸. Both 1 and 2 showed no cytotoxicity against human cancer cell lines HL-60, SU-DHL-2 and U266) at the concentration of 20.0 μM.

Keywords: Aspergillus aureoterreus; cytotoxicity; structure elucidation; α-pyrone polyketide.